Statistical Optimization and Evaluation of a Multi release Unit Bilayer Tablet of Rizatriptan Benzoate

Migraine, a neurological condition is often associated with intense, throbbing, crippling headaches for hours to days. Rizatriptan benzoate has established its potential in controlling the symptoms of migraine. The present study aims formulate bilayer tablet rizatriptan multi release unit matrix embedded sustained layer achieve pulsatile drug control various phases A preliminary on four matrices-F1, F2, F3 and F4 different proportion carnauba wax ethyl cellulose was done evaluate pattern fasted state simulated intestinal fluid at pH 6.5. simplex lattice design used find out optimized ratio matrices dissolution predetermined fashion hour’s intervals. profile blend three formulations (F1:F2:F3=0.53:0.24:0.23). Statistical analysis revealed that percentage error between predicted optimum less than 5 %. immediate formulated direct compression method using super disintegrants. evaluation hardness, weight variation, friability, uniformity content release. met criteria pharmacopoeial requirements. could able instantly as comparable marketed also prolong 24 h. accelerated stability showed tablets retain their property variable temperature humidity. Therefore, it can be concluded polymer deliver rate effective